Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87343
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
8596±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87343
Synonyms:
3-[(2-amino-5-bromo-3-pyridinyl)sulfonylamino]-N-[[4-(dimethylamino)phenyl]methyl]propanamide | 3-[(2-amino-5-bromo-3-pyridyl)sulfonylamino]-N-[4-(dimethylamino)benzyl]propionamide | 3-[(2-amino-5-bromopyridin-3-yl)sulfonylamino]-N-[[4-(dimethylamino)phenyl]methyl]propanamide | 3-[(2-azanyl-5-bromanyl-pyridin-3-yl)sulfonylamino]-N-[[4-(dimethylamino)phenyl]methyl]propanamide | MLS001115260 | SMR000626700 | cid_24792777
Type:
Small organic molecule
Emp. Form.:
C17H22BrN5O3S
Mol. Mass.:
456.357
SMILES:
CN(C)c1ccc(CNC(=O)CCNS(=O)(=O)c2cc(Br)cnc2N)cc1
Structure:
Search PDB for entries with ligand similarity: