Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM87640
Substrate
n/a
Meas. Tech.
Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay
IC50
>66000±n/a nM
Citation
 PubChem, PC Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM87640
Synonyms:
5-[[(5-ethyl-[1,2,4]triazin[5,6-b]indol-3-yl)thio]methyl]furan-2-carboxylic acid methyl ester | 5-[[(5-ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)thio]methyl]-2-furancarboxylic acid methyl ester | MLS000098534 | SMR000065430 | cid_2998128 | methyl 5-[(5-ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanylmethyl]furan-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H16N4O3S
Mol. Mass.:
368.41
SMILES:
CCn1c2ccccc2c2nnc(SCc3ccc(o3)C(=O)OC)nc12
Structure:
Search PDB for entries with ligand similarity: