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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM50449
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
6880±1140 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM50449
Synonyms:
MLS000591126 | N'-[(Z)-3-indolylidenemethyl]-2-[[5-[(4-methylphenyl)methylthio]-1,3,4-thiadiazol-2-yl]thio]acetohydrazide | N'-[(Z)-indol-3-ylidenemethyl]-2-[[5-[(4-methylbenzyl)thio]-1,3,4-thiadiazol-2-yl]thio]acetohydrazide | N'-[(Z)-indol-3-ylidenemethyl]-2-[[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetohydrazide | N'-[(Z)-indol-3-ylidenemethyl]-2-[[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]ethanehydrazide | SMR000218002 | [5-(4-Methyl-benzylsulfanyl)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid [1-(1H-indol-3-yl)-meth-(E)-ylidene]-hydrazide | cid_6506188
Type:
Small organic molecule
Emp. Form.:
C21H19N5OS3
Mol. Mass.:
453.603
SMILES:
Cc1ccc(CSc2nnc(SCC(=O)NN=Cc3c[nH]c4ccccc34)s2)cc1 |w:16.15|
Structure:
Search PDB for entries with ligand similarity: