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Target
Dual specificity protein phosphatase 3
Ligand
BDBM61162
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
3020±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM61162
Synonyms:
3-(6-hydroxy-2-keto-chromen-3-yl)-1-phenyl-pyrazole-4-carbaldehyde | 3-(6-hydroxy-2-oxo-1-benzopyran-3-yl)-1-phenyl-4-pyrazolecarboxaldehyde | 3-(6-hydroxy-2-oxochromen-3-yl)-1-phenylpyrazole-4-carbaldehyde | 3-(6-oxidanyl-2-oxidanylidene-chromen-3-yl)-1-phenyl-pyrazole-4-carbaldehyde | MLS000565419 | SMR000152596 | cid_2319222
Type:
Small organic molecule
Emp. Form.:
C19H12N2O4
Mol. Mass.:
332.3096
SMILES:
Oc1ccc2oc(=O)c(cc2c1)-c1nn(cc1C=O)-c1ccccc1
Structure:
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