Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM88727
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
2450±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM88727
Synonyms:
2-thiophenecarboxylic acid [4-[(E)-[[(3-fluorophenyl)-oxomethyl]hydrazinylidene]methyl]phenyl] ester | 4-[2-(3-fluorobenzoyl)carbonohydrazonoyl]phenyl 2-thiophenecarboxylate | MLS000576933 | SMR000185411 | [4-[(E)-[(3-fluorobenzoyl)hydrazinylidene]methyl]phenyl] thiophene-2-carboxylate | [4-[(E)-[(3-fluorophenyl)carbonylhydrazinylidene]methyl]phenyl] thiophene-2-carboxylate | cid_5332668 | thiophene-2-carboxylic acid [4-[(E)-[(3-fluorobenzoyl)hydrazono]methyl]phenyl] ester
Type:
Small organic molecule
Emp. Form.:
C19H13FN2O3S
Mol. Mass.:
368.382
SMILES:
Fc1cccc(c1)C(=O)N\N=C\c1ccc(OC(=O)c2cccs2)cc1
Structure:
Search PDB for entries with ligand similarity: