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Target
Dual specificity protein phosphatase 3
Ligand
BDBM88758
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
3170±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM88758
Synonyms:
1-(2-phenylethyl)-3-(4-sulfamoylphenyl)thiourea | 1-phenethyl-3-(4-sulfamoylphenyl)thiourea | 4-({[(2-phenylethyl)amino]carbonothioyl}amino)benzenesulfonamide | CHEMBL358290 | MLS000621468 | SMR000299554 | cid_892618
Type:
Small organic molecule
Emp. Form.:
C15H17N3O2S2
Mol. Mass.:
335.444
SMILES:
NS(=O)(=O)c1ccc(NC(=S)NCCc2ccccc2)cc1
Structure:
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