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Target
Dual specificity protein phosphatase 3
Ligand
BDBM88764
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
1120±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM88764
Synonyms:
1-(3-chloranyl-4-methoxy-phenyl)-3-(3-pyrrolidin-1-ylpropyl)thiourea | 1-(3-chloro-4-methoxy-phenyl)-3-(3-pyrrolidinopropyl)thiourea | 1-(3-chloro-4-methoxyphenyl)-3-(3-pyrrolidin-1-ylpropyl)thiourea | 1-(3-chloro-4-methoxyphenyl)-3-[3-(1-pyrrolidinyl)propyl]thiourea | MLS000730543 | N-(3-chloro-4-methoxyphenyl)-N'-(3-pyrrolidin-1-ylpropyl)thiourea | SMR000308819 | cid_16193058
Type:
Small organic molecule
Emp. Form.:
C15H22ClN3OS
Mol. Mass.:
327.873
SMILES:
COc1ccc(NC(=S)NCCCN2CCCC2)cc1Cl
Structure:
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