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Target
Dual specificity protein phosphatase 3
Ligand
BDBM88788
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
2550±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM88788
Synonyms:
(4Z)-1-(3-bromophenyl)-4-(4-morpholin-4-ylbenzylidene)pyrazolidine-3,5-dione | (4Z)-1-(3-bromophenyl)-4-(4-morpholinobenzylidene)pyrazolidine-3,5-quinone | (4Z)-1-(3-bromophenyl)-4-[(4-morpholin-4-ylphenyl)methylidene]pyrazolidine-3,5-dione | (4Z)-1-(3-bromophenyl)-4-[[4-(4-morpholinyl)phenyl]methylidene]pyrazolidine-3,5-dione | MLS001194678 | SMR000554917 | cid_1921067
Type:
Small organic molecule
Emp. Form.:
C20H18BrN3O3
Mol. Mass.:
428.279
SMILES:
Brc1cccc(c1)N1NC(=O)\C(=C\c2ccc(cc2)N2CCOCC2)C1=O
Structure:
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