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Target
Dual specificity protein phosphatase 3
Ligand
BDBM88812
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
3080±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM88812
Synonyms:
6-keto-N-(2-methyl-5-piperidinosulfonyl-phenyl)-1H-pyridine-3-carboxamide | MLS002171654 | N-(2-methyl-5-piperidin-1-ylsulfonyl-phenyl)-6-oxidanylidene-1H-pyridine-3-carboxamide | N-(2-methyl-5-piperidin-1-ylsulfonylphenyl)-6-oxo-1H-pyridine-3-carboxamide | N-[2-methyl-5-(1-piperidinylsulfonyl)phenyl]-6-oxo-1H-pyridine-3-carboxamide | SMR001251947 | cid_4826777
Type:
Small organic molecule
Emp. Form.:
C18H21N3O4S
Mol. Mass.:
375.442
SMILES:
Cc1ccc(cc1NC(=O)c1ccc(=O)[nH]c1)S(=O)(=O)N1CCCCC1
Structure:
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