Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78151
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
3020±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78151
Synonyms:
4-chloro-N'-[(4-chlorobenzoyl)oxy]benzenecarboximidamide | 4-chlorobenzoic acid [(Z)-[amino-(4-chlorophenyl)methylene]amino] ester | 4-chlorobenzoic acid [(Z)-[amino-(4-chlorophenyl)methylidene]amino] ester | MLS000578025 | SMR000187210 | [(Z)-[amino-(4-chlorophenyl)methylidene]amino] 4-chlorobenzoate | [(Z)-[azanyl-(4-chlorophenyl)methylidene]amino] 4-chloranylbenzoate | cid_9567277
Type:
Small organic molecule
Emp. Form.:
C14H10Cl2N2O2
Mol. Mass.:
309.147
SMILES:
NC(=NOC(=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1 |w:2.2|
Structure:
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