Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM77668
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
13000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM77668
Synonyms:
(4-oxidanylidene-1,2,3-benzotriazin-3-yl)methyl 4-(diethylsulfamoyl)benzoate | (4-oxo-1,2,3-benzotriazin-3-yl)methyl 4-(diethylsulfamoyl)benzoate | 4-(diethylsulfamoyl)benzoic acid (4-keto-1,2,3-benzotriazin-3-yl)methyl ester | 4-(diethylsulfamoyl)benzoic acid (4-oxo-1,2,3-benzotriazin-3-yl)methyl ester | MLS000101755 | SMR000017440 | cid_2557756
Type:
Small organic molecule
Emp. Form.:
C19H20N4O5S
Mol. Mass.:
416.451
SMILES:
CCN(CC)S(=O)(=O)c1ccc(cc1)C(=O)OCn1nnc2ccccc2c1=O
Structure:
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