Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM77935
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
987±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM77935
Synonyms:
MLS002165238 | N-(6-amino-1-benzyl-2,4-diketo-pyrimidin-5-yl)-3-methyl-4-nitro-N-propyl-benzamide | N-(6-amino-1-benzyl-2,4-dioxopyrimidin-5-yl)-3-methyl-4-nitro-N-propylbenzamide | N-[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-3-methyl-4-nitro-N-propylbenzamide | N-[6-azanyl-2,4-bis(oxidanylidene)-1-(phenylmethyl)pyrimidin-5-yl]-3-methyl-4-nitro-N-propyl-benzamide | SMR001247605 | cid_4848686
Type:
Small organic molecule
Emp. Form.:
C22H23N5O5
Mol. Mass.:
437.4485
SMILES:
CCCN(C(=O)c1ccc(c(C)c1)[N+]([O-])=O)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O
Structure:
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