Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM89075
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
88000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM89075
Synonyms:
(3E)-3-[1-(6-methyl-1,3-benzothiazol-2-yl)-5-oxidanylidene-2-sulfanylidene-imidazolidin-4-ylidene]-1H-indol-2-one | (3E)-3-[1-(6-methyl-1,3-benzothiazol-2-yl)-5-oxo-2-sulfanylidene-4-imidazolidinylidene]-1H-indol-2-one | (3E)-3-[1-(6-methyl-1,3-benzothiazol-2-yl)-5-oxo-2-sulfanylideneimidazolidin-4-ylidene]-1H-indol-2-one | (3E)-3-[5-keto-1-(6-methyl-1,3-benzothiazol-2-yl)-2-thioxo-imidazolidin-4-ylidene]oxindole | MLS-0463346.0001 | cid_5503309
Type:
Small organic molecule
Emp. Form.:
C19H12N4O2S2
Mol. Mass.:
392.454
SMILES:
Cc1ccc2nc(sc2c1)N1C(=S)NC(C1=O)=C1C(=O)Nc2ccccc12 |w:17.29|
Structure:
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