Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM89122
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
81970±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM89122
Synonyms:
MLS-0463402.0001 | N-[4-[1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-yl]phenyl]acetamide | N-[4-[1,1,1,3,3,3-hexakis(fluoranyl)-2-(trifluoromethyl)propan-2-yl]phenyl]ethanamide | N-[4-[2,2,2-trifluoro-1,1-bis(trifluoromethyl)ethyl]phenyl]acetamide | cid_1580706
Type:
Small organic molecule
Emp. Form.:
C12H8F9NO
Mol. Mass.:
353.1836
SMILES:
CC(=O)Nc1ccc(cc1)C(C(F)(F)F)(C(F)(F)F)C(F)(F)F
Structure:
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