Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM89065
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
4810±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM89065
Synonyms:
4-chlorobenzoic acid [(Z)-[amino-(4-morpholinosulfonylphenyl)methylene]amino] ester | 4-chlorobenzoic acid [(Z)-[amino-[4-(4-morpholinylsulfonyl)phenyl]methylidene]amino] ester | MLS-0454734.0001 | [(Z)-[amino-(4-morpholin-4-ylsulfonylphenyl)methylidene]amino] 4-chlorobenzoate | [(Z)-[azanyl-(4-morpholin-4-ylsulfonylphenyl)methylidene]amino] 4-chloranylbenzoate | cid_9583536
Type:
Small organic molecule
Emp. Form.:
C18H18ClN3O5S
Mol. Mass.:
423.871
SMILES:
Clc1ccc(cc1)C(=O)ONC(=N)c1ccc(cc1)S(=O)(=O)N1CCOCC1
Structure:
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