Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM89088
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
>99000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM89088
Synonyms:
3,7-dimethyl-N-[4-[4-(2-methyl-1-oxopropyl)-1-piperazinyl]phenyl]-5-oxo-6-thiazolo[3,2-a]pyrimidinesulfonamide | 3,7-dimethyl-N-[4-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyrimidine-6-sulfonamide | 3,7-dimethyl-N-[4-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]-5-oxo-[1,3]thiazolo[3,2-a]pyrimidine-6-sulfonamide | MLS-0359383.0001 | N-[4-(4-isobutyrylpiperazino)phenyl]-5-keto-3,7-dimethyl-thiazolo[3,2-a]pyrimidine-6-sulfonamide | cid_15990058
Type:
Small organic molecule
Emp. Form.:
C22H27N5O4S2
Mol. Mass.:
489.611
SMILES:
CC(C)C(=O)N1CCN(CC1)c1ccc(NS(=O)(=O)c2c(C)nc3scc(C)n3c2=O)cc1
Structure:
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