Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77738
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
11200±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77738
Synonyms:
(E)-3-(3,4-dimethoxyphenyl)-N-indan-5-yl-acrylamide | (E)-N-(2,3-dihydro-1H-inden-5-yl)-3-(3,4-dimethoxyphenyl)-2-propenamide | (E)-N-(2,3-dihydro-1H-inden-5-yl)-3-(3,4-dimethoxyphenyl)prop-2-enamide | MLS000388677 | SMR000254850 | cid_2673431
Type:
Small organic molecule
Emp. Form.:
C20H21NO3
Mol. Mass.:
323.3856
SMILES:
COc1ccc(\C=C\C(=O)Nc2ccc3CCCc3c2)cc1OC
Structure:
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