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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89611
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89611
Synonyms:
3-(2-furanylmethyl)-2-[4-(2-oxo-1-benzopyran-3-yl)-1-phenyl-3-pyrazolyl]-4-thiazolidinone | 3-(2-furfuryl)-2-[4-(2-ketochromen-3-yl)-1-phenyl-pyrazol-3-yl]thiazolidin-4-one | 3-(furan-2-ylmethyl)-2-[4-(2-oxidanylidenechromen-3-yl)-1-phenyl-pyrazol-3-yl]-1,3-thiazolidin-4-one | 3-(furan-2-ylmethyl)-2-[4-(2-oxochromen-3-yl)-1-phenylpyrazol-3-yl]-1,3-thiazolidin-4-one | MLS000097959 | SMR000060597 | cid_2998250
Type:
Small organic molecule
Emp. Form.:
C26H19N3O4S
Mol. Mass.:
469.512
SMILES:
O=C1CSC(N1Cc1ccco1)c1nn(cc1-c1cc2ccccc2oc1=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: