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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89616
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89616
Synonyms:
5-N,7-N-diethyl-3-[(4-fluorophenyl)methylsulfanyl]-[1,2,4]triazolo[4,3-a][1,3,5]triazine-5,7-diamine | MLS000096452 | N5,N7-diethyl-3-[(4-fluorophenyl)methylsulfanyl]-[1,2,4]triazolo[4,3-a][1,3,5]triazine-5,7-diamine | N5,N7-diethyl-3-[(4-fluorophenyl)methylthio]-[1,2,4]triazolo[4,3-a][1,3,5]triazine-5,7-diamine | SMR000062236 | cid_2998633 | ethyl-[5-(ethylamino)-3-[(4-fluorobenzyl)thio]-[1,2,4]triazolo[4,3-a][1,3,5]triazin-7-yl]amine
Type:
Small organic molecule
Emp. Form.:
C15H18FN7S
Mol. Mass.:
347.414
SMILES:
CCNc1nc(NCC)n2c(SCc3ccc(F)cc3)nnc2n1
Structure:
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