Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM91530
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2
Temperature
298.15±n/a K
IC50
>99000±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2 PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM91530
Synonyms:
3-(2-phenoxyethylthio)-5-(p-tolyl)thiazolo[2,3-c][1,2,4]triazole | 5-(4-methylphenyl)-3-(2-phenoxyethylsulfanyl)-[1,3]thiazolo[2,3-c][1,2,4]triazole | 5-(4-methylphenyl)-3-(2-phenoxyethylthio)thiazolo[2,3-c][1,2,4]triazole | MLS-0471506.0001 | cid_1587974
Type:
Small organic molecule
Emp. Form.:
C19H17N3OS2
Mol. Mass.:
367.488
SMILES:
Cc1ccc(cc1)-c1csc2nnc(SCCOc3ccccc3)n12
Structure:
