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Target
Tyrosine-protein phosphatase non-receptor type 22
Ligand
BDBM48790
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the Lymphoid Phosphatase (PTPN22) Inhibition Assay
IC50
35569±3850 nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the Lymphoid Phosphatase (PTPN22) Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 22
Synonyms:
3.1.3.48 | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP | LyP | Lymphoid phosphatase | Lymphoid phosphatase (Lyp) | PEP | PEST-domain phosphatase | PTN22_HUMAN | PTPN22 | PTPN8 | Tyrosine-protein phosphatase non-receptor type 22 (LYP) | tyrosine-protein phosphatase non-receptor type 22 isoform 1
Type:
n/a
Mol. Mass.:
91712.31
Organism:
Homo sapiens (Human)
Description:
Q9Y2R2
Residue:
807
Sequence:
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSEISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSCFVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQESAVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTSEPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIETYSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNSSSFLNFGFANRFSKPKGPRNPPPTWNI
  
Inhibitor
Name:
BDBM48790
Synonyms:
2-[3-(1,3-benzothiazol-2-yl)phenyl]-1,3-bis(oxidanylidene)isoindole-5-carboxylic acid | 2-[3-(1,3-benzothiazol-2-yl)phenyl]-1,3-diketo-isoindoline-5-carboxylic acid | 2-[3-(1,3-benzothiazol-2-yl)phenyl]-1,3-dioxo-5-isoindolecarboxylic acid | 2-[3-(1,3-benzothiazol-2-yl)phenyl]-1,3-dioxo-5-isoindolinecarboxylic acid | 2-[3-(1,3-benzothiazol-2-yl)phenyl]-1,3-dioxoisoindole-5-carboxylic acid | MLS000676593 | SMR000298477 | cid_1339774
Type:
Small organic molecule
Emp. Form.:
C22H12N2O4S
Mol. Mass.:
400.407
SMILES:
OC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1cccc(c1)-c1nc2ccccc2s1
Structure:
Search PDB for entries with ligand similarity: