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Target
Sentrin-specific protease 8
Ligand
BDBM83941
Substrate
n/a
IC50
2080±434 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM83941
Synonyms:
6-methyl-8H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 6-methyl-8H-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone | MLS001048964 | SMR000008544 | cid_5351216
Type:
Small organic molecule
Emp. Form.:
C6H5N5O2
Mol. Mass.:
179.1362
SMILES:
Cn1c(=O)[nH]c2nncnc2c1=O
Structure:
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