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Target
Caspase-3
Ligand
BDBM93691
Substrate
n/a
IC50
48300±2470 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 in a Caspase-3 Fluorescence assay PubChem Bioassay (2012)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM93691
Synonyms:
1-[2-(5-nitro-2-thienyl)-5-phenyl-2H-1,3,4-oxadiazol-3-yl]ethanone | 1-[2-(5-nitro-2-thiophenyl)-5-phenyl-2H-1,3,4-oxadiazol-3-yl]ethanone | 1-[2-(5-nitrothiophen-2-yl)-5-phenyl-2H-1,3,4-oxadiazol-3-yl]ethanone | 3-acetyl-2-(5-nitrothien-2-yl)-5-phenyl-2,3-dihydro-1,3,4-oxadiazole | MLS000724537 | SMR000306130 | cid_3693334
Type:
Small organic molecule
Emp. Form.:
C14H11N3O4S
Mol. Mass.:
317.32
SMILES:
CC(=O)N1N=C(OC1c1ccc(s1)[N+]([O-])=O)c1ccccc1 |c:4|
Structure:
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