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Target
Protein Wnt-3a
Ligand
BDBM83552
Substrate
n/a
IC50
1320±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM83552
Synonyms:
2-(1,3-Dimethyl-2,6-dioxo-7-propyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-N-[4-(4-methoxy-phenyl)-thiazol-2-yl]-acetamide | 2-(1,3-dimethyl-2,6-dioxo-7-propylpurin-8-yl)sulfanyl-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]acetamide | 2-[(1,3-dimethyl-2,6-dioxo-7-propyl-8-purinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide | 2-[(2,6-diketo-1,3-dimethyl-7-propyl-purin-8-yl)thio]-N-[4-(4-methoxyphenyl)thiazol-2-yl]acetamide | 2-[1,3-dimethyl-2,6-bis(oxidanylidene)-7-propyl-purin-8-yl]sulfanyl-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]ethanamide | MLS000564486 | SMR000172615 | cid_3172868
Type:
Small organic molecule
Emp. Form.:
C22H24N6O4S2
Mol. Mass.:
500.594
SMILES:
CCCn1c(SCC(=O)Nc2nc(cs2)-c2ccc(OC)cc2)nc2n(C)c(=O)n(C)c(=O)c12
Structure:
Search PDB for entries with ligand similarity: