Reaction Details
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Corticotropin-releasing factor-binding protein
Ligand
BDBM63534
Substrate
n/a
IC50
675±n/a nM
Citation
PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
Inhibitor
Name:
BDBM63534
Synonyms:
8-methoxy-3-(5-phenyl-1,3,4-oxadiazol-2-yl)-1-benzopyran-2-one | 8-methoxy-3-(5-phenyl-1,3,4-oxadiazol-2-yl)chromen-2-one | 8-methoxy-3-(5-phenyl-1,3,4-oxadiazol-2-yl)coumarin | MLS000687822 | SMR000284886 | cid_748239
Type:
Small organic molecule
Emp. Form.:
C18H12N2O4
Mol. Mass.:
320.2989
SMILES:
COc1cccc2cc(-c3nnc(o3)-c3ccccc3)c(=O)oc12
Structure:
