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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM54464
Substrate
n/a
IC50
20000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM54464
Synonyms:
MLS001066639 | N-(4,6-difluoro-1,3-benzothiazol-2-yl)-5-nitro-2-furamide | N-(4,6-difluoro-1,3-benzothiazol-2-yl)-5-nitro-2-furancarboxamide | N-(4,6-difluoro-1,3-benzothiazol-2-yl)-5-nitrofuran-2-carboxamide | N-[4,6-bis(fluoranyl)-1,3-benzothiazol-2-yl]-5-nitro-furan-2-carboxamide | SMR000640856 | cid_2307752
Type:
Small organic molecule
Emp. Form.:
C12H5F2N3O4S
Mol. Mass.:
325.248
SMILES:
[O-][N+](=O)c1ccc(o1)C(=O)Nc1nc2c(F)cc(F)cc2s1
Structure:
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