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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM91366
Substrate
n/a
IC50
1330±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM91366
Synonyms:
(1S,12bS)-3-[2-[[(2E)-3,7-dimethylocta-2,6-dienyl]amino]-2-keto-ethyl]-N,N-diethyl-4-keto-9-methoxy-12b-methyl-1,2,3,6,7,12-hexahydropyrido[2,1-a]-carboline-1-carboxamide | (1S,12bS)-3-[2-[[(2E)-3,7-dimethylocta-2,6-dienyl]amino]-2-oxidanylidene-ethyl]-N,N-diethyl-9-methoxy-12b-methyl-4-oxidanylidene-1,2,3,6,7,12-hexahydroindolo[2,3-a]quinolizine-1-carboxamide | (1S,12bS)-3-[2-[[(2E)-3,7-dimethylocta-2,6-dienyl]amino]-2-oxoethyl]-N,N-diethyl-9-methoxy-12b-methyl-4-oxo-1,2,3,6,7,12-hexahydroindolo[2,3-a]quinolizine-1-carboxamide | MLS002608821 | SMR001530050 | cid_44601757
Type:
Small organic molecule
Emp. Form.:
C34H48N4O4
Mol. Mass.:
576.7693
SMILES:
CCN(CC)C(=O)[C@H]1CC(CC(=O)NC\C=C(/C)CCC=C(C)C)C(=O)N2CCc3c([nH]c4ccc(OC)cc34)[C@]12C |wD:40.44,7.6,(13.59,-2.49,;13.13,-1.02,;11.63,-.68,;10.58,-1.81,;11.04,-3.28,;11.17,.79,;9.67,1.13,;12.21,1.92,;13.78,1.58,;14.85,2.77,;16.36,2.46,;16.84,.99,;15.81,-.16,;18.35,.68,;18.83,-.78,;20.34,-1.1,;20.82,-2.56,;19.79,-3.71,;22.33,-2.88,;22.81,-4.34,;24.32,-4.65,;24.8,-6.12,;26.3,-6.43,;23.77,-7.26,;14.34,4.29,;15.36,5.45,;12.77,4.6,;12.29,6.07,;10.79,6.39,;9.76,5.24,;10.23,3.78,;8.99,2.88,;7.75,3.78,;6.2,3.42,;5.12,4.6,;5.61,6.12,;4.59,7.26,;3.08,6.95,;7.18,6.44,;8.23,5.24,;11.74,3.46,;10.71,2.31,)|
Structure:
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