Reaction Details
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Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Ligand
BDBM94655
Substrate
n/a
IC50
20903±n/a nM
Citation
PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Synonyms:
ASAP1 | ASAP1_HUMAN | DDEF1 | KIAA1249 | PAG2 | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
125507.11
Organism:
Homo sapiens (Human)
Description:
Q9ULH1
Residue:
1129
Sequence:
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
Inhibitor
Name:
BDBM94655
Synonyms:
2-[2-(2,6-dimethylmorpholin-4-yl)-2-oxidanylidene-ethyl]sulfanyl-7-methyl-pyrido[1,2-a][1,3,5]triazin-4-one | 2-[2-(2,6-dimethylmorpholin-4-yl)-2-oxoethyl]sulfanyl-7-methylpyrido[1,2-a][1,3,5]triazin-4-one | 2-[[2-(2,6-dimethyl-4-morpholinyl)-2-oxoethyl]thio]-7-methyl-4-pyrido[1,2-a][1,3,5]triazinone | 2-[[2-(2,6-dimethylmorpholino)-2-keto-ethyl]thio]-7-methyl-pyrido[1,2-a][1,3,5]triazin-4-one | MLS001234975 | SMR000810924 | cid_18573499
Type:
Small organic molecule
Emp. Form.:
C16H20N4O3S
Mol. Mass.:
348.42
SMILES:
CC1CN(CC(C)O1)C(=O)CSc1nc2ccc(C)cn2c(=O)n1
Structure:
