Reaction Details
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Xylosyl- and glucuronyltransferase LARGE1
Ligand
BDBM94734
Substrate
n/a
EC50
28500±n/a nM
Citation
PubChem, PC Dose response confirmation of small molecule activators of alpha dystroglycan glycosylation PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Xylosyl- and glucuronyltransferase LARGE1
Synonyms:
KIAA0609 | LARG1_HUMAN | LARGE | LARGE1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
88079.63
Organism:
Homo sapiens (Human)
Description:
gi_47678551
Residue:
756
Sequence:
MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS
Inhibitor
Name:
BDBM94734
Synonyms:
5-[2-(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanoylamino]benzene-1,3-dicarboxamide | 5-[[1-oxo-2-[(2,5,6-trimethyl-4-thieno[2,3-d]pyrimidinyl)thio]ethyl]amino]benzene-1,3-dicarboxamide | 5-[[2-(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetyl]amino]benzene-1,3-dicarboxamide | 5-[[2-[(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)thio]acetyl]amino]isophthalamide | MLS001007073 | SMR000384470 | cid_2548636
Type:
Small organic molecule
Emp. Form.:
C19H19N5O3S2
Mol. Mass.:
429.516
SMILES:
Cc1sc2nc(C)nc(SCC(=O)Nc3cc(cc(c3)C(N)=O)C(N)=O)c2c1C
Structure:
