Reaction Details Report a problem with these data
Target
Sentrin-specific protease 1
Ligand
BDBM52244
Substrate
n/a
IC50
5940±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM52244
Synonyms:
1-(4-chlorophenyl)-4-oxidanylidene-7-phenyl-3-(phenylmethyl)pyrimido[1,2-b]pyridazin-5-ium-2-olate | 1-(4-chlorophenyl)-4-oxo-7-phenyl-3-(phenylmethyl)-2-pyrimido[1,2-b]pyridazin-5-iumolate | 3-benzyl-1-(4-chlorophenyl)-4-keto-7-phenyl-pyrimido[1,2-b]pyridazin-5-ium-2-olate | 3-benzyl-1-(4-chlorophenyl)-4-oxo-7-phenyl-4H-pyrimido[1,2-b]pyridazin-1-ium-2-olate | 3-benzyl-1-(4-chlorophenyl)-4-oxo-7-phenylpyrimido[1,2-b]pyridazin-5-ium-2-olate | MLS000594496 | SMR000113828 | cid_3518713
Type:
Small organic molecule
Emp. Form.:
C26H18ClN3O2
Mol. Mass.:
439.893
SMILES:
[O-]c1c(Cc2ccccc2)c(=O)n(-c2ccc(Cl)cc2)c2ccc(n[n+]12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: