Reaction Details
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Sentrin-specific protease 1
Ligand
BDBM94783
Substrate
n/a
IC50
15400±n/a nM
Citation
PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
Inhibitor
Name:
BDBM94783
Synonyms:
MLS000575772 | SMR000196808 | [1,1-diketo-2-methyl-4-(p-toluidino)-1,2-benzothiazin-3-yl]-phenyl-methanone | [2-methyl-4-(4-methylanilino)-1,1-dioxo-1,2-benzothiazin-3-yl]-phenylmethanone | [2-methyl-4-[(4-methylphenyl)amino]-1,1-bis(oxidanylidene)-1,2-benzothiazin-3-yl]-phenyl-methanone | cid_1326081 | {2-methyl-4-[(4-methylphenyl)amino]-1,1-dioxido-2H-1,2-benzothiazin-3-yl}(phenyl)methanone
Type:
Small organic molecule
Emp. Form.:
C23H20N2O3S
Mol. Mass.:
404.482
SMILES:
CN1C(C(=O)c2ccccc2)=C(Nc2ccc(C)cc2)c2ccccc2S1(=O)=O |t:11|
Structure:
