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Target
Sentrin-specific protease 1
Ligand
BDBM94779
Substrate
n/a
IC50
6050±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94779
Synonyms:
2-(2-allyloxyethyl)-4,7-diphenyl-3a,4,7,7a-tetrahydroisoindole-1,3-quinone | 2-[2-(allyloxy)ethyl]-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione | 4,7-diphenyl-2-(2-prop-2-enoxyethyl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione | MLS000534880 | SMR000142315 | cid_2944998
Type:
Small organic molecule
Emp. Form.:
C25H25NO3
Mol. Mass.:
387.4709
SMILES:
C=CCOCCN1C(=O)C2C(C(C=CC2c2ccccc2)c2ccccc2)C1=O |c:12|
Structure:
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