Reaction Details Report a problem with these data
Target
Sentrin-specific protease 1
Ligand
BDBM69795
Substrate
n/a
IC50
18100±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM69795
Synonyms:
5-bromanyl-2-[(2Z)-2-[5-cyano-4-methyl-2,6-bis(oxidanylidene)pyridin-3-ylidene]hydrazinyl]benzoic acid | 5-bromo-2-[(2Z)-2-(5-cyano-4-methyl-2,6-dioxo-3-pyridinylidene)hydrazinyl]benzoic acid | 5-bromo-2-[(2Z)-2-(5-cyano-4-methyl-2,6-dioxopyridin-3-ylidene)hydrazinyl]benzoic acid | 5-bromo-2-[(N'Z)-N'-(5-cyano-2,6-diketo-4-methyl-3-pyridylidene)hydrazino]benzoic acid | MLS001213177 | SMR000542932 | cid_5813804
Type:
Small organic molecule
Emp. Form.:
C14H9BrN4O4
Mol. Mass.:
377.15
SMILES:
CC1=C(C#N)C(=O)NC(=O)C1=NNc1ccc(Br)cc1C(O)=O |w:11.12,c:1|
Structure:
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