Reaction Details Report a problem with these data
Target
Sentrin-specific protease 1
Ligand
BDBM94843
Substrate
n/a
IC50
1930±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94843
Synonyms:
(5R)-5-(1,3-benzodioxol-5-yl)-3-(3-chloranyl-2-oxidanyl-phenyl)cyclohex-2-en-1-one | (5R)-5-(1,3-benzodioxol-5-yl)-3-(3-chloro-2-hydroxy-phenyl)cyclohex-2-en-1-one | (5R)-5-(1,3-benzodioxol-5-yl)-3-(3-chloro-2-hydroxyphenyl)-1-cyclohex-2-enone | (5R)-5-(1,3-benzodioxol-5-yl)-3-(3-chloro-2-hydroxyphenyl)cyclohex-2-en-1-one | (R)-5-(benzo[d][1,3]dioxol-5-yl)-3-(3-chloro-2-hydroxyphenyl)cyclohex-2-enone | MLS001060926 | SMR000568157 | cid_42628166
Type:
Small organic molecule
Emp. Form.:
C19H15ClO4
Mol. Mass.:
342.773
SMILES:
Oc1c(Cl)cccc1C1=CC(=O)C[C@@H](C1)c1ccc2OCOc2c1 |t:9|
Structure:
Search PDB for entries with ligand similarity: