Reaction Details
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Sentrin-specific protease 1
Ligand
BDBM94849
Substrate
n/a
IC50
14200±n/a nM
Citation
PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
Inhibitor
Name:
BDBM94849
Synonyms:
9,10,10-triketo-N-(2-methoxyethyl)-6-morpholino-thioxanthene-1-carboxamide | MLS002472291 | N-(2-methoxyethyl)-6-(4-morpholinyl)-9,10,10-trioxo-1-thioxanthenecarboxamide | N-(2-methoxyethyl)-6-morpholin-4-yl-9,10,10-trioxothioxanthene-1-carboxamide | N-(2-methoxyethyl)-6-morpholin-4-yl-9,10,10-tris(oxidanylidene)thioxanthene-1-carboxamide | SMR001395442 | cid_44144209
Type:
Small organic molecule
Emp. Form.:
C21H22N2O6S
Mol. Mass.:
430.474
SMILES:
COCCNC(=O)c1cccc2c1C(=O)c1ccc(cc1S2(=O)=O)N1CCOCC1
Structure:
