Reaction Details Report a problem with these data
Target
Hepatocyte nuclear factor 4-alpha
Ligand
BDBM50470
Substrate
n/a
IC50
1417±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization PubChem Bioassay (2012)[AID] 
Target
Name:
Hepatocyte nuclear factor 4-alpha
Synonyms:
HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b
Type:
PROTEIN
Mol. Mass.:
52790.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_606516
Residue:
474
Sequence:
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
  
Inhibitor
Name:
BDBM50470
Synonyms:
2-[[5,6-bis(2-furanyl)-1,2,4-triazin-3-yl]thio]-N-(3-methylphenyl)acetamide | 2-[[5,6-bis(2-furyl)-1,2,4-triazin-3-yl]thio]-N-(m-tolyl)acetamide | 2-[[5,6-bis(furan-2-yl)-1,2,4-triazin-3-yl]sulfanyl]-N-(3-methylphenyl)acetamide | 2-[[5,6-bis(furan-2-yl)-1,2,4-triazin-3-yl]sulfanyl]-N-(3-methylphenyl)ethanamide | MLS000855932 | SMR000286377 | cid_6403907
Type:
Small organic molecule
Emp. Form.:
C20H16N4O3S
Mol. Mass.:
392.431
SMILES:
Cc1cccc(NC(=O)CSc2nnc(-c3ccco3)c(n2)-c2ccco2)c1
Structure:
Search PDB for entries with ligand similarity: