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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95240
Substrate
n/a
IC50
>164757±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95240
Synonyms:
MLS003120506 | N-(3-acetylphenyl)-3-(1-methyl-4-pyrazolyl)-7-benzofurancarboxamide | N-(3-acetylphenyl)-3-(1-methylpyrazol-4-yl)-1-benzofuran-7-carboxamide | N-(3-acetylphenyl)-3-(1-methylpyrazol-4-yl)benzofuran-7-carboxamide | N-(3-ethanoylphenyl)-3-(1-methylpyrazol-4-yl)-1-benzofuran-7-carboxamide | SMR001289880 | cid_46948162
Type:
Small organic molecule
Emp. Form.:
C21H17N3O3
Mol. Mass.:
359.378
SMILES:
CC(=O)c1cccc(NC(=O)c2cccc3c(coc23)-c2cnn(C)c2)c1
Structure:
Search PDB for entries with ligand similarity: