Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 22
Ligand
BDBM88926
Substrate
n/a
IC50
13600±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in a fluorescence-based, Lymphoid Phosphatase (PTPN22, LYP-1) selectivity Assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 22
Synonyms:
3.1.3.48 | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP | LyP | Lymphoid phosphatase | Lymphoid phosphatase (Lyp) | PEP | PEST-domain phosphatase | PTN22_HUMAN | PTPN22 | PTPN8 | Tyrosine-protein phosphatase non-receptor type 22 (LYP) | tyrosine-protein phosphatase non-receptor type 22 isoform 1
Type:
n/a
Mol. Mass.:
91712.31
Organism:
Homo sapiens (Human)
Description:
Q9Y2R2
Residue:
807
Sequence:
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSEISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSCFVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQESAVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTSEPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIETYSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNSSSFLNFGFANRFSKPKGPRNPPPTWNI
  
Inhibitor
Name:
BDBM88926
Synonyms:
4-[[3-[4-[oxo-[(2E)-2-(1-pyridin-4-ylethylidene)hydrazinyl]methyl]phenoxy]-1,4-dioxan-2-yl]oxy]-N-[(E)-1-pyridin-4-ylethylideneamino]benzamide | MLS001013427 | N-[(E)-1-(4-pyridyl)ethylideneamino]-4-[[3-[4-[[(E)-1-(4-pyridyl)ethylideneamino]carbamoyl]phenoxy]-1,4-dioxan-2-yl]oxy]benzamide | N-[(E)-1-pyridin-4-ylethylideneamino]-4-[[3-[4-[[(E)-1-pyridin-4-ylethylideneamino]carbamoyl]phenoxy]-1,4-dioxan-2-yl]oxy]benzamide | SMR000353410 | cid_9614065
Type:
Small organic molecule
Emp. Form.:
C32H30N6O6
Mol. Mass.:
594.6172
SMILES:
CC(=NNC(=O)c1ccc(OC2OCCOC2Oc2ccc(cc2)C(=O)NN=C(C)c2ccncc2)cc1)c1ccncc1 |w:27.28,2.2|
Structure:
Search PDB for entries with ligand similarity: