Reaction Details Report a problem with these data
Target
RecBCD enzyme subunit RecD
Ligand
BDBM73586
Substrate
n/a
IC50
101515±n/a nM
Citation
 PubChem, PC Absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2013)[AID] 
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
  
Inhibitor
Name:
BDBM73586
Synonyms:
4-[(2,6-diketo-4,4-dimethyl-cyclohexylidene)methylamino]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide | 4-[(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide | 4-[[4,4-dimethyl-2,6-bis(oxidanylidene)cyclohexylidene]methylamino]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide | 4-{[(4,4-dimethyl-2,6-dioxocyclohexylidene)methyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide | MLS000682889 | SMR000312972 | cid_4098595
Type:
Small organic molecule
Emp. Form.:
C19H22N4O4S2
Mol. Mass.:
434.532
SMILES:
[#6]-[#6]-c1nnc(-[#7]S(=O)(=O)c2ccc(-[#7]\[#6]=[#6]-3/[#6](=O)-[#6]C([#6])([#6])[#6]-[#6]-3=O)cc2)s1
Structure:
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