Reaction Details Report a problem with these data
Target
RecBCD enzyme subunit RecD
Ligand
BDBM80057
Substrate
n/a
IC50
66923±n/a nM
Citation
 PubChem, PC Absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2013)[AID] 
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
  
Inhibitor
Name:
BDBM80057
Synonyms:
MLS002607898 | N-[4-(5-nitrofuran-2-yl)sulfanylphenyl]acetamide | N-[4-(5-nitrofuran-2-yl)sulfanylphenyl]ethanamide | N-[4-[(5-nitro-2-furanyl)thio]phenyl]acetamide | N-[4-[(5-nitro-2-furyl)thio]phenyl]acetamide | SMR001526660 | cid_234636
Type:
Small organic molecule
Emp. Form.:
C12H10N2O4S
Mol. Mass.:
278.284
SMILES:
CC(=O)Nc1ccc(Sc2ccc(o2)[N+]([O-])=O)cc1
Structure:
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