Reaction Details Report a problem with these data
Target
Activin receptor type-1B
Ligand
BDBM280337
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay Inhibition of ALK1/2/3/4/5/6 Kinases
IC50
32.5±n/a nM
Citation
 Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent  US10030004 Publication Date 7/24/2018 
Target
Name:
Activin receptor type-1B
Synonyms:
ACV1B_HUMAN | ACVR1B | ACVRLK4 | ALK4 | Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4)
Type:
PROTEIN
Mol. Mass.:
56810.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_587064
Residue:
505
Sequence:
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
  
Inhibitor
Name:
BDBM280337
Synonyms:
(S)-4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyridyl]amino]-N-(2-hydroxy propyl)pyridine-3-carboxamide | US10030004, Compound 2a | US10501436, Compound 2a | US11053216, Compound 2a | US11702401, Compound 2a
Type:
Small organic molecule
Emp. Form.:
C23H24ClFN4O2
Mol. Mass.:
442.914
SMILES:
C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1cc(Cl)ccc1F |r|
Structure:
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