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Target
Monoacylglycerol lipase ABHD2
Ligand
BDBM280607
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
550±n/a nM
Citation
 Cisar, JS; Grice, CA; Jones, TK; Weber, OD; Buzard, DJ; Shaghafi, MB Spirocycle compounds and methods of making and using same US Patent  US10030020 Publication Date 7/24/2018 
Target
Name:
Monoacylglycerol lipase ABHD2
Synonyms:
2-arachidonoylglycerol hydrolase | ABHD2_MOUSE | Abhd2 | Abhydrolase domain-containing protein 2 | Labh-2 | Labh2 | Lung alpha/beta hydrolase 2 | MmLABH2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48378.90
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
425
Sequence:
MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKRTYPQTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKSQCSDTEQMEAELE
  
Inhibitor
Name:
BDBM280607
Synonyms:
US10030020, Example 152 | US10781211, Example 152
Type:
Small organic molecule
Emp. Form.:
C21H25F7N2O2
Mol. Mass.:
470.4242
SMILES:
CCc1cc(CN2CCC3(C2)CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)ccc1F
Structure:
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