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Target
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Ligand
BDBM52774
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-B3)
IC50
122491±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-B3) PubChem Bioassay (2014)[AID] 
Target
Name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Synonyms:
PLCB3 | PLCB3_HUMAN | Phospholipase C, beta 3 (phosphatidylinositol-specific) | Phospholipase C-beta-3
Type:
PROTEIN
Mol. Mass.:
138786.29
Organism:
Homo sapiens (Human)
Description:
EBI_12586
Residue:
1234
Sequence:
MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLGDGPLVACASNGHAPGSSGHLSGADSESQEENTQL
  
Inhibitor
Name:
BDBM52774
Synonyms:
(2Z)-2-(4-ethylbenzylidene)-6-hydroxy-7-[[4-(2-hydroxyethyl)piperazino]methyl]coumaran-3-one | (2Z)-2-[(4-ethylphenyl)methylidene]-6-hydroxy-7-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-3-benzofuranone | (2Z)-2-[(4-ethylphenyl)methylidene]-6-hydroxy-7-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]-1-benzofuran-3-one | (2Z)-2-[(4-ethylphenyl)methylidene]-7-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]-6-oxidanyl-1-benzofuran-3-one | 2-[1-(4-Ethyl-phenyl)-meth-(Z)-ylidene]-6-hydroxy-7-[4-(2-hydroxy-ethyl)-piperazin-1-ylmethyl]-benzofura n-3-one | MLS000779077 | SMR000415760 | cid_1836181
Type:
Small organic molecule
Emp. Form.:
C24H28N2O4
Mol. Mass.:
408.4901
SMILES:
CCc1ccc(\C=C2/Oc3c(ccc(O)c3CN3CCN(CCO)CC3)C2=O)cc1
Structure:
Search PDB for entries with ligand similarity: