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Target
Major prion protein
Ligand
BDBM66153
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1382±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM66153
Synonyms:
6,8-bis(bromanyl)-4-piperidin-1-yl-quinazoline | 6,8-dibromo-4-(1-piperidinyl)quinazoline | 6,8-dibromo-4-piperidin-1-ylquinazoline | 6,8-dibromo-4-piperidino-quinazoline | MLS000038796 | SMR000040604 | cid_659524
Type:
Small organic molecule
Emp. Form.:
C13H13Br2N3
Mol. Mass.:
371.07
SMILES:
Brc1cc(Br)c2ncnc(N3CCCCC3)c2c1
Structure:
Search PDB for entries with ligand similarity: