Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114311
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1923±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114311
Synonyms:
1-[1-[4-amino-6-(N-phenylanilino)-1,3,5-triazin-2-yl]-5-methyl-4-triazolyl]ethanone | 1-[1-[4-amino-6-(N-phenylanilino)-1,3,5-triazin-2-yl]-5-methyltriazol-4-yl]ethanone | 1-[1-[4-amino-6-(N-phenylanilino)-s-triazin-2-yl]-5-methyl-triazol-4-yl]ethanone | 1-[1-[4-azanyl-6-(diphenylamino)-1,3,5-triazin-2-yl]-5-methyl-1,2,3-triazol-4-yl]ethanone | 1-{1-[4-amino-6-(diphenylamino)-1,3,5-triazin-2-yl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone | MLS000045653 | SMR000027610 | cid_1510815
Type:
Small organic molecule
Emp. Form.:
C20H18N8O
Mol. Mass.:
386.4099
SMILES:
CC(=O)c1nnn(c1C)-c1nc(N)nc(n1)N(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: