Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM95259
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
142.56±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM95259
Synonyms:
3,4-dimethyl-2-(4-methylphenyl)-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazine-7-thione | 3,4-dimethyl-2-(4-methylphenyl)-6H-pyrazolo[3,4-d]pyridazine-7-thione | 3,4-dimethyl-2-(p-tolyl)-6H-pyrazolo[3,4-d]pyridazine-7-thione | MLS000325312 | SMR000161327 | cid_1234246
Type:
Small organic molecule
Emp. Form.:
C14H14N4S
Mol. Mass.:
270.353
SMILES:
Cc1n(nc2c1c(C)n[nH]c2=S)-c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: