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Target
Major prion protein
Ligand
BDBM66190
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1919±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM66190
Synonyms:
2-amino-6-(dicyanomethylene)-4-phenyl-1H-pyridine-3,5-dicarbonitrile | 2-amino-6-(dicyanomethylidene)-4-phenyl-1H-pyridine-3,5-dicarbonitrile | 2-azanyl-6-(dicyanomethylidene)-4-phenyl-1H-pyridine-3,5-dicarbonitrile | MLS001163959 | SMR000539348 | cid_910973
Type:
Small organic molecule
Emp. Form.:
C16H8N6
Mol. Mass.:
284.2749
SMILES:
Nc1nc(C(C#N)C#N)c(C#N)c(-c2ccccc2)c1C#N
Structure:
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