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Target
Fibrinogen beta chain [164-491]
Ligand
BDBM114658
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer
IC50
83309±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] PubChem Bioassay (2013)[AID] 
Target
Name:
Fibrinogen beta chain [164-491]
Synonyms:
Chain E, Fragment Double-D From Human Fibrin | FGB | FIBB_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37647.12
Organism:
Homo sapiens (Human)
Description:
gi_28373962
Residue:
328
Sequence:
DNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
  
Inhibitor
Name:
BDBM114658
Synonyms:
Benzofuran-2-carboxylic acid [1-(1-prop-2-ynyl-1H-indol-3-yl)-meth-(E)-ylidene]-hydrazide | MLS000587256 | N-[(E)-(1-prop-2-ynyl-3-indolyl)methylideneamino]-2-benzofurancarboxamide | N-[(E)-(1-prop-2-ynylindol-3-yl)methylideneamino]-1-benzofuran-2-carboxamide | N-[(E)-(1-propargylindol-3-yl)methyleneamino]coumarilamide | SMR000211308 | cid_6883561
Type:
Small organic molecule
Emp. Form.:
C21H15N3O2
Mol. Mass.:
341.3627
SMILES:
O=C(N\N=C\c1cn(CC#C)c2ccccc12)c1cc2ccccc2o1
Structure:
Search PDB for entries with ligand similarity: