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Target
Protein artemis
Ligand
BDBM114681
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay
IC50
20000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay PubChem Bioassay (2013)[AID] 
Target
Name:
Protein artemis
Synonyms:
ARTEMIS | ASCID | DCLRE1C | DCR1C_HUMAN | SCIDA | SNM1C | protein artemis isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
78427.91
Organism:
Homo sapiens (Human)
Description:
gi_76496497
Residue:
692
Sequence:
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAELPKREHLQYLYEKLATGESIAVKKRKCSLLDT
  
Inhibitor
Name:
BDBM114681
Synonyms:
MLS000090598 | N-(6-methoxy-1,3-benzothiazol-2-yl)-1-(2-thienylsulfonyl)nipecotamide | N-(6-methoxy-1,3-benzothiazol-2-yl)-1-(thien-2-ylsulfonyl)piperidine-3-carboxamide | N-(6-methoxy-1,3-benzothiazol-2-yl)-1-thiophen-2-ylsulfonyl-3-piperidinecarboxamide | N-(6-methoxy-1,3-benzothiazol-2-yl)-1-thiophen-2-ylsulfonyl-piperidine-3-carboxamide | N-(6-methoxy-1,3-benzothiazol-2-yl)-1-thiophen-2-ylsulfonylpiperidine-3-carboxamide | SMR000025202 | cid_3244802
Type:
Small organic molecule
Emp. Form.:
C18H19N3O4S3
Mol. Mass.:
437.556
SMILES:
COc1ccc2nc(NC(=O)C3CCCN(C3)S(=O)(=O)c3cccs3)sc2c1
Structure:
Search PDB for entries with ligand similarity: