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Target
Protein artemis
Ligand
BDBM64586
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay
IC50
4680±n/a nM
Citation
 PubChem, PC Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay PubChem Bioassay (2013)[AID] 
Target
Name:
Protein artemis
Synonyms:
ARTEMIS | ASCID | DCLRE1C | DCR1C_HUMAN | SCIDA | SNM1C | protein artemis isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
78427.91
Organism:
Homo sapiens (Human)
Description:
gi_76496497
Residue:
692
Sequence:
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAELPKREHLQYLYEKLATGESIAVKKRKCSLLDT
  
Inhibitor
Name:
BDBM64586
Synonyms:
3-Hydroxy-2-{N'-[1-(2-hydroxy-naphthalen-1-yl)-meth-(E)-ylidene]-hydrazino}-3H-quinazolin-4-one | 3-hydroxy-2-[2-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]hydrazinyl]quinazolin-4-one | 3-hydroxy-2-[N'-[(Z)-(2-keto-1-naphthylidene)methyl]hydrazino]quinazolin-4-one | 3-hydroxy-2-[[(Z)-(2-oxo-1-naphthalenylidene)methyl]hydrazo]-4-quinazolinone | 3-oxidanyl-2-[2-[(Z)-(2-oxidanylidenenaphthalen-1-ylidene)methyl]hydrazinyl]quinazolin-4-one | MLS000551780 | SMR000145705 | cid_6532827
Type:
Small organic molecule
Emp. Form.:
C19H14N4O3
Mol. Mass.:
346.3395
SMILES:
Oc1ccc2ccccc2c1CN=Nc1nc2ccccc2c(=O)n1O |w:13.15|
Structure:
Search PDB for entries with ligand similarity: